解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.01.001
更新日期:2008-06-01 00:00:00
abstract::The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.02.002
更新日期:2008-06-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.11.001
更新日期:2008-02-01 00:00:00
abstract::The tetra-peptide FMRF-NH(2) is a cardioexcitatory peptide in the clam. Using the antibody against this peptide, FMRF-NH(2)-like immunoreactive material was detected in mammalian CNS. Subsequently, mammalian FMRF-NH(2) immunoreactive peptides were isolated from bovine brain and characterized to be FLFQPQRF-NH(2) (NPFF...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2007.06.004
更新日期:2008-02-01 00:00:00
abstract::Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.10.004
更新日期:2008-02-01 00:00:00
abstract::Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.08.003
更新日期:2007-12-01 00:00:00
abstract::The role of somatostatin on inhibition of both normal and tumor cell cycle, secretion of endocrine and exocrine cells, as well as induction apoptosis is well documented. However, its effect on T cell development and thymic structure is not fully clarified. In order to investigate the influence of somatostatin in vivo ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.06.003
更新日期:2007-12-01 00:00:00
abstract::During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.10.002
更新日期:2007-02-01 00:00:00
abstract::Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.06.003
更新日期:2006-08-01 00:00:00
abstract::Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2006.04.002
更新日期:2006-08-01 00:00:00
abstract::Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.02.001
更新日期:2006-06-01 00:00:00
abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2005.10.001
更新日期:2006-02-01 00:00:00
abstract::Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.12.009
更新日期:2005-06-01 00:00:00
abstract::In the present study, electrophysiological recordings were made from hippocampal slices obtained from mice overexpressing galanin under the promoter for the platelet-derived growth factor-B (GalOE mice). In these mice, a particularly strong galanin expression is seen in the granule cell layer/mossy fibers. Paired-puls...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2005.02.005
更新日期:2005-06-01 00:00:00
abstract::Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carboh...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.12.022
更新日期:2005-06-01 00:00:00
abstract::The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title:Neuropeptides
pub_type:
doi:10.1016/j.npep.2005.03.002
更新日期:2005-06-01 00:00:00
abstract::To study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA le...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.11.002
更新日期:2005-04-01 00:00:00
abstract::We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.07.004
更新日期:2004-12-01 00:00:00
abstract::Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.05.009
更新日期:2004-08-01 00:00:00
abstract::The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2003.10.001
更新日期:2003-12-01 00:00:00
abstract::Both endothelins and corticotropin releasing factor (CRF) appear in capsaicin-sensitive neurons. We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism. With the aid of tachyphylaxis to capsaicin (i...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00048-9
更新日期:2003-08-01 00:00:00
abstract::Brain extracts from 3 to 4 day old final (eighth) instar larvae of Opisina arenosella (Lepidoptera) stimulate amylase release from midgut preparations maintained in vitro. This effect of the brain extract was both time and dose dependent. The brain factor stimulating enzyme release may be a peptide as it is heat stabl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00025-8
更新日期:2003-06-01 00:00:00
abstract::In vivo microdialysis was employed to explore the effects of different selective non-peptides NK(1),NK(2) and NK(3) receptor antagonists on the corticotropin releasing factor (CRF)-induced release of acetylcholine (ACh) in the hippocampus of rats and guinea-pigs. In both species, the intracerebroventricular (i.c.v.) a...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00019-2
更新日期:2003-04-01 00:00:00
abstract::The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(02)00135-x
更新日期:2003-02-01 00:00:00
abstract:RATIONALE:Cholecystokinin and its analogs generate anxiety in humans and measurable anxiety-like behaviors in rats. Cholecystokinin receptor blockers have been reported to have variable effects in the treatment of anxiety disorders. We demonstrated that intracerebroventricular administration of Cholecystokinin-antisens...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(02)00088-4
更新日期:2002-10-01 00:00:00
abstract::Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(02)00029-x
更新日期:2002-08-01 00:00:00
abstract::The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2002.0892
更新日期:2002-04-01 00:00:00
abstract::Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2002.0889
更新日期:2002-04-01 00:00:00
abstract::The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2002.0869
更新日期:2002-02-01 00:00:00
abstract::In rats anaesthetized with urethane single unit activity was extracellularly recorded in the neostriatum, and several drugs were microiontophoretically ejected. Separate administration of the sulfated octapeptide cholecystokinin (CCK-8S), serotonin (5-HT) or 8-OH-DPAT (a 5-HT(1A/7) receptor agonist) predominantly indu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2001.0875
更新日期:2001-10-01 00:00:00
abstract::Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.0...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2001.0863
更新日期:2001-06-01 00:00:00
abstract::Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0843
更新日期:2001-02-01 00:00:00
abstract::Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNT...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0829
更新日期:2000-12-01 00:00:00
abstract::The anatomical distribution of Substance P (SP) has been investigated since the development of antibodies against it in the 1970s. Although initial studies were performed with antibodies that also recognised the other endogenous neurokinins, most of the initial descriptions are surprisingly still valid today. In this ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2000.0834
更新日期:2000-10-01 00:00:00
abstract::We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0813
更新日期:2000-06-01 00:00:00
abstract::The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0800
更新日期:2000-04-01 00:00:00
abstract::Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0788
更新日期:2000-02-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0768
更新日期:1999-12-01 00:00:00